His main interests are: political ecology, ontological design, and the anthropology of development, social movements, and technoscience. Over the past twenty-five years, he has worked closely with several Afro-Colombian social movements in the Colombian Pacific, particular the Process of Black Communities (PCN).  His most well-known book is Encountering Development: The Making and Unmaking of the Third World (1995).  His most recent books are: Designs for the Pluriverse: Radical Interdependence, Autonomy, and the Making of Worlds (2018), and Pluriversal Politics: The Real and the Possible (2020).